Fever Phobia- Supportive studies on why we should support fever rather than suppress it.
- Cammy Benton MD
- Dec 4, 2018
- 2 min read
Updated: Sep 29
Organized Research on Fever Management in Children
1. Physician Knowledge & Practice Patterns
Knowledge, attitudes and misconceptions of primary care physicians regarding fever in children: a cross sectional study
Fever management: Evidence vs current practice
Highlights the common but unsupported practice of alternating antipyretics.
2. Comparing Antipyretic Methods
Comparison of cold water sponging and acetaminophen in control of fever among children in Nigeria
Paracetamol for treating fever in children
Cochrane Review: No conclusive superiority over placebo; similar effects to physical methods.
Physical methods for treating fever in children
3. Acetaminophen (Tylenol) and Biological Effects
Acetaminophen decreases intracellular glutathione and modulates cytokine production
Tylenol lowers glutathione levels (body’s key antioxidant)
4. Risks of Antipyretic Therapy in Infections
Antipyretic therapy may increase mortality in viral infections
Treatment with NSAIDs or acetaminophen increased 28-day mortality in sepsis
Suppression of fever increases influenza cases and deaths in US models
Virus shedding prolonged in animals when fever is suppressed
Animal models show increased mortality from antipyretics in influenza
5. Fever in Sepsis & Critical Illness
Control of Fever in Septic Shock: Should We Care or Intervene?
Fever and antipyresis in infection
Should fever be reduced in septic patients?
6. General Reviews & Guidance
A Practical Approach to the Treatment of Low-Risk Childhood Fever
Fever: Suppress it or let it ride?
Overuse of antipyretics despite weak evidence of benefit
7. Educational Resources
When should I be worried? (short video, with humor and balanced advice)
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